UCSB    Yuedong Wang 


Areas of Interest
  • smoothing splines
  • statistical computing
  • biostatistical modelling: renal diseases, human circadian rhythm, ...
  • microarray data analysis
  • reliability



Yuedong Wang, Smoothing Splines: Methods and Applications, Chapman & Hall/CRC Monographs on Statistics & Applied Probability, 2011. Click here for online information.

Publications by year:

Pending, 2014, 2013, 2012, 2011, 2009, 2008, 2007, 2006, 2005, 2004, 2003, 2002, 2001, 2000, 1999,
1998, 1997, 1996, 1995, 1994, 1993, 1992, 1991, 1990 1988



  • Len A Usvyat, Jeroen P Kooman, Frank M van der Sande, Yuedong Wang, Franklin W Maddux, Nathan W Levin and Peter Kotanko, Dynamics of hospitalizations in hemodialysis patients: results from a large US provider, Nephrology Dialysis Transplantation, 29:442-448 (PubMed).
  • Y Chen, P Du and Y Wang, Variable selection in linear models, Wiley Interdisciplinary Reviews: Computational Statistics, 6:1-9 (Wiley Online).
  • T Cornelis, LA Usvyat, JH Tordoir, Y Wang, M Wong, KM Leunissen, FM van der Sande1, P Kotanko, JP Kooman (2014), Vascular Access Vulnerability in Intensive Hemodialysis: a Significant Achilles' Heel?, Blood Purification, 37:222-228 (PubMed).


  • Len A. Usvyat, Yosef S. Haviv, Michael Etter, Jeroen Kooman, Daniele Marcelli, Cristina Marelli, Albert Power, Ted Toffelmire, Yuedong Wang, and Peter Kotanko, The MONitoring Dialysis Outcomes (MONDO) Initiative, Blood Purification,35:37-48 (PubMed).
  • Len A Usvyat, Claudia Barth, Inga Bayh, Michael Etter, Gero D von Gersdorff, Aileen Grassmann, Adrian M Guinsburg, Maggie Lam, Daniele Marcelli, Cristina Marelli, Laura Scatizzi, Mathias Schaller, Adam Tashman, Ted Toffelmire, Stephan Thijssen, Jeroen P Kooman, Frank M van der Sande, Nathan W Levin, Yuedong Wang and Peter Kotanko, Interdialytic weight gain, systolic blood pressure, serum albumin, and C-reactive protein levels change in chronic dialysis patients prior to death, Kidney International,84:149-157 (PubMed).
  • Johanna Kuipers, Len A. Usvyat, Jurjen K. Oosterhuis, Judith J. Dasselaar, Paul E. de Jong, Ralf Westerhuis, Jeffrey J. Sands, Yuedong Wang, Peter Kotanko, and Casper F.M. Franssen, Variability of predialytic, intradialytic, and postdialytic blood pressures in the course of a week: a study of Dutch and US maintenance hemodialysis patients, American Journal of Kidney Disease, 62:779-788 (PubMed).
  • RJ Ingham, Y Wang, JC Ingham, AK Bothe and ST Grafton, Regional brain activity change predicts responsiveness to treatment for stuttering in adults, Brain and Language,127:510-519 (PubMed).
  • GD von Gersdorff, L Usvyat, D Marcelli, A. Grassmann, C. Marelli, M. Etter, JP Kooman, A. Power, T Toffelmire, YS Haviv, A Guinsburg A, C Barth, M Schaller, I Bayh, L Scatizzi, A Tashman, S Thijssen, NW Levin, FM van der Sande, C Pusey, Y Wang and P Kotanko, Monitoring Dialysis Outcomes across the World - The MONDO Global Database Consortium, Blood Purification, 36:165-172 (PubMed).


  • Jeffrey C. Sklar, Junqing Wu, Wendy Meiring, and Yuedong Wang, Non-parametric Regression with Basis Selection from Multiple Libraries, Technometrics,55:189-201 (pdf) and ( Supplement)
  • Tiejun Tong, Yanyuan Ma and Yuedong Wang, Optimal variance estimation without estimating the mean function, Bernoulli,19:1839-1854.
  • Tiejun Tong, Homin Jang and Yuedong Wang, James-Stein Type Estimators of Variances, Journal of Multivariate Analysis, 107:232-243. (pdf)
  • Nikolay Bliznyuk, Raymond Carroll, Marc Genton and Yuedong Wang, Variogram Estimation in the Presence of Trend, Statistics and Its Interface,5:159-168. (pdf)
  • Roger Ingham, Anne Bothe, Yuedong Wang, Krystal Purkhiser and Anneliese New, Phonation interval modification and speech performance quality during fluency-inducing conditions by adults who stutter,Journal of Communication Disorders, 45198-211 (PubMed).
  • Zaixing Li, Yuedong Wang, Ping Wu, Wangli Xu and Lixing Zhu, Tests for Variance Components in Varying Coefficient Mixed Models,Statistica Sinica,22:123-148. (pdf)


  • Pang Du, Yihua Jiang, Yuedong Wang, Smoothing spline ANOVA frailty model for recurrent event data, Biometrics, 67:1330-1339 (pdf)
  • Xiaoyan Mao, Yuedong Wang, Drew Carter, Xuechu Zhen, Sun-Wei Guo, The Retardation of Myometrial Infiltration, Reduction of Uterine Contractility and Alleviation of Generalized Hyperalgesia in Mice with Induced Adenomyosis by Levo-Tetrahydropalmatine (l-THP) and Andrographolide, Reproductive Sciences, 18:1025-1037. (PubMed).
  • Yihua Jiang, Peter Karcher and Yuedong Wang (2011), On Implementation of the Markov Chain Monte Carlo Stochastic Approximation Algorithm. "Advances in Directional and Linear Statistics, A Festschrift for Sreenivasa Rao Jammalamadaka", M Wells and A Sengupta (eds), Springer. (pdf)


  • Yuedong Wang, Yanyuan Ma and Raymond J Carroll (2009), Variance Estimation in the Analysis of Microarray Data, Journal of the Royal Statistical Society B,71:425-445. (Complete paper including Supplemental Materials).
  • Yuedong Wang and Chunlei Ke (2009), Smoothing Spline Semi-parametric Nonlinear Regression Models, Journal of Computational and Graphical Statistics,18165-183. (pdf)
  • Shuangge Ma and Yuedong Wang (2009), Frontiers of Biostatistics and Bioinformatics, University of Science and Technology of China Press, Hefei, China.


  • Raymond J Carroll and Yuedong Wang (2008), Nonparametric variance estimation in the analysis of microarray data: a measurement error approach. Biometrika, 95:437-449. ( Complete paper including Supplemental Materials).
  • Tiejun Tong, Anna Liu and Yuedong Wang, Relative errors of difference-based variance estimators in nonparametric regression. Communications in Statistics - Theory and Methods, 37:2890-2902.
  • Xishi Liu, Lei Yuan, Yuedong Wang, Fanghua Shen and Sun-Wei Guo (2008), Risk Factors For Dysmenorrhea and Its Severity in Women with Ovarian Endometriomas. Gynecologic and Obstetric Investigation, 66(3):169-177. (PubMed).
  • Fanghua Shen, Yuedong Wang, Yuan Lu, Xishi Liu and Sun-Wei Guo (2008), Immunoreactivity of progesterone receptor isoform B and nuclear factor kappa-B as biomarkers for recurrence of ovarian endometriomas. American Journal of Obstetrics and Gynecology, 199:486.e1-486.e10. (PubMed).
  • Li Qin and Yuedong Wang (2008), Nonparametric Spectral Analysis With Applications to Seizure Characterization Using EEG Time Series. Annals of Applied Statistics, 2:1432-1451. (pdf).


  • Tiejun Tong and Yuedong Wang (2007), Optimal Shrinkage Estimation of Variances with Applications to Microarray Data Analysis, Journal of the American Statistical Association, 102:113-122. ( pdf).
  • Anna Liu, Tiejun Tong and Yuedong Wang (2007), Smoothing Spline Estimation of Variance Functions, Journal of Computational and Graphical Statistics, 16:312-329. ( pdf).
  • Anna Liu and Yuedong Wang (2007), Modeling of Hormone Secretion-Generating Mechanisms With Splines: A Pseudo-Likelihood Approach. Biometrics, 63:201-208. ( pdf).
  • Sun-Wei Guo, Yuedong Wang, Xishi Liu and David L. Olive (2007), Laterality and Asymmetry of Endometriotic Lesions. Fertility and Sterility, 89:33-41. (PubMed).


  • Wu Y, Kajdacsy-Balla A, Strawn E, Basir Z, Halverson G, Jailwala P, Wang Y, Wang X, Ghosh S, Guo SW (2006), Transcriptional Characterizations of Differences between Eutopic and Ectopic Endometrium. Endocrinology 147(1):232-246. (PubMed).
  • Wu Y, Strawn E, Basir Z, Wang Y, Halverson G, Jailwala P, Guo SW (2006), Genomic alterations in the ectopic and eutopic endometrium of women with endometriosis. Gynecologic and Obstetric Investigation, 62(3):148-159. (PubMed).
  • Guo SW and Wang Y (2006), The prevalence of endometriosis in women with chronic pelvic pain. Gynecologic and Obstetric Investigation, 62:121-130. (PubMed).
  • Guo SW and Wang Y (2006), Sources of Heterogeneities in the Estimation of Prevalence of Endometriosis in Infertile and Previously Fertile Women. Fertility and Sterility, 86(6):1584-95. (PubMed).


  • Yu-Chieh Yang, Anna Liu and Yuedong Wang (2005), Detecting Pulsatile Hormone Secretions Using Nonlinear Mixed Effects Partial Spline Models, Biometrics, 62:230-238. ( ps, pdf).
  • Anna Liu, Wendy Meiring and Yuedong Wang (2005), Testing Generalized Linear Models Using Smoothing Spline Methods. Statistica Sinica, 15:235-256 ( ps, pdf).
  • Tiejun Tong and Yuedong Wang (2005), Estimating residual variance in nonparametric regression using least squares. Biometrika 92:821-830 ( ps, pdf).


  • Yuedong Wang and Sunwei Guo (2004), Statistical Methods for Detecting Genomic Alterations Through Array-Based Comparative Genomic Hybridization (CGH). Frontiers in Bioscience, 9:540-549. (PubMed)
  • Anna Liu and Yuedong Wang (2004), Hypothesis Testing in Smoothing Spline Models. Journal of Statistical Computation and Simulation, 74:581-597 ( ps, pdf).
  • Yuedong Wang (2004), Model Selection. Book chapter in "Handbook of Computational Statistics (Volume I)", J. Gentle, W. Hardle, Y. Mori (eds), Springer.
  • Chunlei Ke and Yuedong Wang (2004), Nonlinear Nonparametric Regression Models. Journal of the American Statistical Association 99:1166-1175 (ps, pdf). Click here to get the bond data we used in this paper. Proofs and technical arguments ( ps, pdf)
  • Guo SW, Wu Y, Strawn E, Basir Z, Wang Y, Halverson G, Montgomery K, Kajdacsy-Balla A. (2004). Genomic Alterations in the endometrium may be a proximate cause for endometriosis. Eur J Obstet Gynecol Reprod Biol. 116:89-99. (PubMed).


  • Yuedong Wang, Chunlei Ke and Morton B. Brown (2003), Shape Invariant Modelling of Circadian Rhythms with Random Effects and Smoothing Spline ANOVA Decompositions. Biometrics, 59:804-812 (ps, pdf).


  • Chunlei Ke and Yuedong Wang (2002), ASSIST: A Suite of S-plus functions Implementing Spline smoothing Techniques, (ps, pdf).


  • Peter Karcher and Yuedong Wang (2001), Generalized Nonparametric Mixed Effects Models, Journal of Computational and Graphical Statistics, 10:641-655. (ps, pdf)
  • J.D. Opsomer, Y. Wang and Y. Yang (2001), Nonparametric regression with correlated errors, Statistical Science, 16:134-153. (pdf).
  • Chunlei Ke and Yuedong Wang (2001), Semi-parametric Nonlinear Mixed Effects Models and Their applications (with discussion). Journal of the American Statistical Association, 96:1272-1298. (ps, pdf).


  • Yuedong Wang, Wensheng Guo and Morton B. Brown (2000), Spline Smoothing For Bivariate Data With Applications To Association Between Hormones, Statistica Sinica, 10:377-397 (ps, pdf)


  • Wensheng Guo, Yuedong Wang and Morton B. Brown (1999), A Signal Extraction Approach to Modeling Hormone Time Series with Pulses and a Changing Baseline. Journal of the American Statistical Association, 94:746-756 (ps, pdf)


  • Yuedong Wang (1998), Mixed-Effects Smoothing Spline ANOVA, Journal of the Royal Statistical Society B, 60:159-174 (ps, pdf). Click here to get programs I used in this paper or here to get modified programs for SAS version 6.12.
  • Yuedong Wang (1998), Smoothing Spline Models With Correlated Random Errors, Journal of the American Statistical Association, 93:341-348 (ps, pdf) Click here to get programs I used in this paper or here to get modified programs for SAS version 6.12.
  • Yuedong Wang (1998), Sample Size Calculations for Smoothing Splines Based on Bayesian Confidence Intervals, Statistics and Probability Letters, 38:161-166 (ps, pdf)
  • J. M. Bowen, G. E. Dahl, N. P. Evans, L. A. Thrun, Yuedong Wang, Morton B. Brown, F. J. Karsch (1998), Importance of the GnRH Surge for Induction of the Preovulatory LH Surge of the Ewe: Dose-Response Relationship and Excess in GnRH, Endocrinology, 139:588-595. (PubMed)
  • Yuedong Wang and Wahba, G. (1998), Discussion of "Smoothing Spline Models for the Analysis of Nested and Crossed Samples of Curves" by Brumback and Rice, Journal of the American Statistical Association, 93:976-980 (ps, pdf)
  • SW Guo, FM Shen, Yuedong Wang, CJ Zheng (1998), Threshold distribution of phenylthiocarbamide (PTC) in the Chinese population, The Annals of the New York Academy of Sciences, 855:810-812. (PubMed).


  • Yuedong Wang (1997), Odds Ratio Estimation in Bernoulli Smoothing Spline ANOVA Models, Statistician,48:49-56 (ps, pdf)
  • Yuedong Wang (1997), GRKPACK: Fitting Smoothing Spline ANOVA Models for Exponential Families, Communications in Statistics: Simulation and Computation, 26:765-782 (ps, pdf)
  • Yuedong Wang, Grace Wahba, Chong Gu, Ronald Klein and Barbara Klein (1997), Using Smoothing Spline ANOVA to Examine the Relation of Risk Factors to the Incidence and Progression of Diabetic Retinopathy, Statistics in Medicine,16:1357-1376 (ps, pdf)


  • Yuedong Wang and Morton M. Brown (1996), A Flexible Model For Human Circadian Rhythms, Biometrics, 52: 588-596 (ps, pdf)


  • Yuedong Wang and Grace Wahba (1995), Bootstrap Confidence Intervals for Smoothing Spline Estimates and Their Comparison to Bayesian Confidence Intervals, Journal of Statistical Computation and Simulation, 51:263-279 (ps, pdf).
  • Grace Wahba and Yuedong Wang (1995), Behavior Near Zero of the Distribution of the GCV Smoothing Parameter Estimates, Statistics and Probability Letters, 25:105-111 (ps, pdf).
  • Wahba, G., Wang, Y., Gu, C., Klein, R. and Klein, B. (1995), Smoothing spline ANOVA for exponential families, with application to Wisconsin Epidemiological study of diabetic retinopathy, Annals of Statistics, 23:1865-1895 (ps, pdf)
  • Yuedong Wang, Grace Wahba, Rick Chappell and Chong Gu (1995), Simulation Studies of Smoothing Parameter Estimates and Bayesian Confidence Intervals in Bernoulli SS ANOVA Models, Communications in Statistics: Simulation and Computation, 24:1037-1059 (ps, pdf)
  • Jinhua Cao and Yuedong Wang (1995), The EBELC and EWELC Classes of Life Distributions, Microelectronics and Reliability, 35:969-971.


  • Grace Wahba, Chong Gu, Yuedong Wang and Rick Chappell (1994), Soft Classification, a.k.a. Risk Estimation, Via Penalized Log Likelihood and Smoothing Spline Analysis of Variance, The Mathematics of Generalization, Santa Fe Institute Studies in the Science of Complexity, Vol. XX, 329-360, D. Wolpert, eds, Santa Fe Institute Studies in the Sciences of Complexity, Addison Wesley.
  • Yuedong Wang and Jinhua Cao (1994), Some Multivariate DMRL and NBUE Definitions Based on Conditional Stochastic Order, Acta Mathematicae Applicatae Sinica (Engl. Edn.), 10328-332.
  • Jinhua Cao and Yuedong Wang (1994), The NBELC and NWELC Classes of Life Distributions, Applied Mathematics, A Journal of Chinese Universities (Engl. Edn.), 9:237-244.


  • Grace Wahba, Yuedong Wang, Chong Gu, Ronald Klein and Barbara Klein (1993), Structured Machine Learning for 'Soft Classification' with Smoothing Spline ANOVA and Stacked Tuning, Testing and Evaluation, Advances in Neural Information Processing 6, Cowan, J.D., Tesauro, G. and Alspector, J. (eds.), San Francisco, CA: Morgan Kaufmann Publishers, 415-422.


  • Jinhua Cao and Yuedong Wang (1992), Characterization Problem of Superposition of Two Renewal Processes, Chinese Journal of Applied Probability and Statistics,888-93.


  • Jinhua Cao and Yuedong Wang (1991), Pure Birth Shock Models In Changing Environments, Math. Stat. and Appl. Prob. (In Chinese), 6:123-127.
  • Jinhua Cao and Yuedong Wang (1991), The NBUC and NWUC Classes of Life Distributions, J. Appl. Prob., 28:473-479.


  • Yuedong Wang (1990), Combined Wear and Shock Failure Model, Math. Stat. and Appl. Prob. (In Chinese), 6:123-126.
  • Yuedong Wang and Jinhua Cao (1990), New Kinds of Multivariate IFR Distribution, Adv. Appl. Prob., 22251-253.
  • Jinhua Cao and Yuedong Wang (1990), Optimal Allocation For a Repairable System, Microelectronics and Reliability, 30:1091-1093.
  • Qiming He, Yuedong Wang and Daozhi Zhang (1990), On the First Failure Time of Two-Unit Systems in Two Environments, Microelectronics and Reliability, 30:1095-1097.


  • Yuedong Wang (1988), Failure Distributions of Generalized Shock Models and Their Application, Chinese Journal of Applied Probability and Statistics, 3:240-247.
  • Yuedong Wang (1988), Multivariate Shock Models, J. of the Graduate School, USTC, Academia Sinica (In Chinese), 5:1-9.

Other Publications

There are various other papers and reports by Yuedong Wang and coworkers in Prof. Wahba's web site of the Department of Statistics, University of Wisconsin-Madison.

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